RT Book, Section A1 Bianchi, Diana W. A1 Crombleholme, Timothy M. A1 D'Alton, Mary E. A1 Malone, Fergal D. SR Print(0) ID 1106398771 T1 Cloacal Exstrophy T2 Fetology: Diagnosis and Management of the Fetal Patient, 2e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 978-0-07-144201-5 LK obgyn.mhmedical.com/content.aspx?aid=1106398771 RD 2024/03/28 AB Key PointsArises from maldevelopment of the cloacal membrane, which prevents migration of mesenchymal tissue and impedes normal development of the lower abdominal wall.Consists of exstrophy of the urinary bladder, exstrophy of the small or large intestine, anal atresia, hypoplasia of the colon, omphalocele, and malformed genitalia.Incidence 1 in 200,000 to 400,000 livebirths.Associated sonographic signs may include: large infraumbilical anterior midline defect with a protruding omphalocele, absent bladder, narrowed thorax, distorted spine, sacral myelomeningocele, and bilateral clubfeet. However, a correct prenatal diagnosis is rarely made.Differential diagnosis includes bladder exstrophy, omphalocele, gastroschisis, amniotic band syndrome, myelomeningocele, and the limb–body wall deformity.Management of pregnancy should include MRI, karyotype, and multidisciplinary consultation with surgery, urology, endocrinology, and genetics.Delivery should occur in a tertiary center.If the fetus is genetically male, the parents should be counseled about the potential need to reassign gender.