RT Book, Section
A1 Bianchi, Diana W.
A1 Crombleholme, Timothy M.
A1 D'Alton, Mary E.
A1 Malone, Fergal D.
SR Print(0)
ID 1106401000
T1 Neuroblastoma
T2 Fetology: Diagnosis and Management of the Fetal Patient, 2e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-144201-5
LK obgyn.mhmedical.com/content.aspx?aid=1106401000
RD 2024/10/14
AB Key  PointsMost  common  solid  tumor  in  infants.Neuroblastomas  are  generally  diagnosed  by  sonography  in  the  third  trimester,  and  can  be  cystic,  solid,  or  both.The  differential  diagnosis  includes  hydronephrosis,  multicystic  kidney,  obstructive  duplex  collecting  system,  Wilms’  tumor,  mesoblastic  nephroma,  and  adrenal  hemorrhage.Neuroblastoma  in  situ  may  be  responsible  for  many  prenatally  diagnosed  cystic  neuroblastomas,  and  may  be  due  to  delayed  regression  of  neuroblasts.83%  of  prenatally  diagnosed  neuroblastomas  will  be  localized  stage  I  or  II  disease.Neuroblastoma  is  stage  III  or  IVS  in  only  16%  of  cases.Poor  prognostic  signs,  such  as  N-myc  amplification,  occur  in  less  than  5%  of  cases.Prenatal  complications  such  as  fetal  hydrops,  hepatomegaly,  and  maternal  hypertension  occur  rarely.