RT Book, Section A1 Lowery, William J. A1 Chino, Junzo A1 Havrilesky, Laura J. A2 Karlan, Beth Y. A2 Bristow, Robert E. A2 Li, Andrew J. SR Print(0) ID 1106570660 T1 Vaginal Cancer T2 Gynecologic Oncology: Clinical Practice and Surgical Atlas YR 2015 FD 2015 PB McGraw-Hill Medical PP New York, NY SN 9780071749268 LK obgyn.mhmedical.com/content.aspx?aid=1106570660 RD 2024/10/10 AB Primary vaginal cancer is an uncommon gynecologic malignancy and constitutes only 1% to 2% of gynecologic malignancies. Because of its rarity, there are specific guidelines for the diagnosis of primary vaginal cancer. A malignancy located in the vagina and not involving any adjacent pelvic organs is considered to be a primary vaginal cancer. If the malignancy extends to the cervix or vulva, it is considered a primary lesion of the nonvaginal site. Based on the observation that 95% of patients with recurrent cervical cancer will experience relapse within 5 years, all squamous cell carcinomas identified in the vagina within this period are defined as recurrences. Only those squamous cell carcinomas found more than 5 years after the diagnosis of cervical cancer are defined as primary vaginal cancers.1 If there is a history of endometrial cancer, a diagnosis of adenocarcinoma in the vagina is usually considered a recurrence regardless of the time from primary treatment.