RT Book, Section A1 Coleman, Robert L. A1 Sabbatini, Paul J. A2 Karlan, Beth Y. A2 Bristow, Robert E. A2 Li, Andrew J. SR Print(0) ID 1106572124 T1 Targeted Therapy and Immunotherapy T2 Gynecologic Oncology: Clinical Practice and Surgical Atlas YR 2015 FD 2015 PB McGraw-Hill Medical PP New York, NY SN 9780071749268 LK obgyn.mhmedical.com/content.aspx?aid=1106572124 RD 2024/04/19 AB While simplistic in its view, the effectors of the immune system are generally divided into those components that support innate immunity and those that support acquired immunity. The classification suggests a dichotomous relationship, but there is necessary and frequent cross-talk between the 2 arms. Innate immunity is active from birth, is the first line of defense against most pathogens, and does not require modification for activity. Acquired immunity largely requires activation of B lymphocytes and T lymphocytes and uses a complex process of activation, modification, expansion, and suppression in response to changing stimuli.